Hematological and immune disorders in colorectal cancer patients with liver metastases after radiofrequency ablation

Background. Colorectal cancer (CRC) is one of the most common malignant neoplasms in world. It ranks third structure oncological morbidity and second mortality. The liver site metastatic spread CR 14 to 18% patients have metastases at diagnosis. Radiofrequency ablation currently promising method treating lesions.
 Рurpose – study quantitative changes hematoimmunological indicators their influence on antitumor reactivity with colorectal after RFA metastases.
 Materials Methods. Clinical laboratory examination was carried out 12 liver, majority were over 60 years old. Adenocarcinoma histologically determined all patients, them had a moderate degree malignancy (G2). three stages: I day before radiofrequency (RFA), II 3 days RFA, III Results. Immune hematological development inflammatory response established. On 3rd (II stage) significant increase total number leukocytes, ratio neutrophils lymphocytes, eosinophils, violation balance CD4+ CD8+ decrease NK- NKT-cells, an percentage CD3+ HLA-Dr -, CD4 +PD1+, CD8+PD1+ lymphocytes. 14th (stage III), parameters close those treatment, except for reduced NK NKT cells level platelets.
 Conclusions. A related reaction identified: neutrophils/lymphocytes from 1.72 4.12, relative absolute eosinophils. But day, subsided, normalization studied observed. subpopulation composition lymphocytes established RFA. Those that taken place even intervention (low cells) additional ones appeared (increased CD4+/CD8+ ratio, increased HLA-Dr+, PD1+ (CD279+), cells). picture approached initial one, exception cells. We believe timely correction immunosuppression early can shorten period vulnerability recurrence CR, long term potentiate positive effect reactivity.